Flowchart of dehydroepiandrosterone DHEA studies identified in the literature. This may be due to diminished or enhanced activity of 17, lyase. This enzyme is not only essential for fat tissue production, but also promotes cancer cell growth. Results indicated that supplementing with DHEA improved erectile dysfunction. Adrenal androgens and cortisol production are not always linked. In contrast, the production of testosterone in premenopausal women is approximately 0. The problem of an abnormal ratio of TE can easily be diagnosed with a simple blood test for estradiol. The decline of DHEA is associated with age-related disease processes such as heart disease and bone loss.
Scientists don't know everything DHEA does. The potential value of DHEA therapy for women still requires exploration in adequately powered well-designed randomised placebo-controlled trials. This process has been termed intracrinology Labrie et al. This enzyme is not only essential for fat tissue production, but also promotes cancer cell growth. Overall, the interpretation of data from randomised controlled trials conducted in well women is limited by inadequate sample size and short treatment durations with inconsistent results for the outcomes of libido and wellbeing. In order for testosterone to do its job, it must be in the free form and not bound to other circulating proteins like sex hormone binding globulin SHBG. Independent effects of DHEA There is still considerable uncertainty as to whether DHEA has significant physiological actions independent of its conversion to other estrogenic and androgenic steroids. In contrast, the production of testosterone in premenopausal women is approximately 0. The dosage is 50mgday. Men who take DHEA-containing supplements may see significant benefits. Flowchart of dehydroepiandrosterone DHEA studies identified in the literature. Dehydroepiandrosterone DHEA and its sulphate DHEAS are the most abundant circulating sex steroid hormones in women, providing a large precursor reservoir for the intracellular production of androgens and oestrogens in non-reproductive tissues. Also excess estrogen increases the production of SHBG and blocks the testosterone-receptor sites. It has also been reported to protect bone mineral density in women. This mechanism serves to eliminate the exposure of other tissues to androgens or estrogens, thus minimizing unwanted side effects Labrie, ; Labrie et al. The transformation of DHEA and DHEAS into androgens and estrogens in the peripheral tissues depends on the level of expression of the steroidogenic and metabolizing enzymes present in the tissues. This may be due to diminished or enhanced activity of 17, lyase. Search terms used included DHEA, DHEAS, dehydroepiandrosterone, dehydroepiandrosterone sulphate, in combination with the terms randomized trial, androgen replacement, adrenal insufficiency, menopause, libido and wellbeing. The analysis provided is purely descriptive as the published studies do not provide adequate data for inclusion in a meta-analysis. Since DHEA can increase testosterone levels, critical to muscle tissue development, you may notice an improvement in your lean body mass. Building up the adrenal gland Strengthening the immune system Slowing natural changes in the body that come with age Providing more energy Building up bone and muscle strength DHEA Supplements for Anti-Aging Since DHEA levels decline with age, some researchers speculate that supplementing your body's falling levels of the hormone might help fight aging. The decline of DHEA is associated with age-related disease processes such as heart disease and bone loss. The production of DHEA peaks in your early 20's, after which it begins dropping by approximately 10 percent each decade. However this is not supported by the published literature. But a similar number of studies have reported no effect. DHEA is converted into testosterone, which is known to enhance libido in both men and women.
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DHEA - Energy, Stamina, Libido, Well-Being, ++
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